PADI3 and alopecia: We also identified two hair disorders due to mutations in the PAD3 encoding gene: A rare hair shaft dysplasia called uncombable hair syndrome (UHS; OMIM#191480, #617251, and #617252) [22], and a particular form of alopecia, the Central Centrifugal Cicatricial Alopecia (CCCA, OMIM%618352), affecting up to 5% of women of African ancestry and the most common type of primary scarring alopecia [23].