At present, clinically the most relevant therapeutic uses for anti-PD-(L)1-anti-CTLA-4 antibody combinations are in advanced melanoma [113], RCC [114], and NSCLC [115], anti-PD-(L)1 antibody -chemo in lung cancers [116,117] and triple-negative breast cancer [118], and anti-PD-(L)1 antibody -TKI in RCC [119]. The gene discussed is CTLA4; the disease is melanoma.