ALK and non-small cell lung carcinoma: Of the tumor single-gene alterations, the most prominent evidence of the predictive role exists in NSCLC with genes such as STK11, KEAP1, K-Ras, EGFR, and ALK. STK11 is a tumor suppressor gene that is inactivated e.g., in NSCLC and melanoma [69,70], and in NSCLC, mutations in STK11 have been shown to relate to a lack of response to immunotherapy.