In addition, SREBP decoy ODN decreased AST, ALT, total cholesterol, and triglyceride levels in the serum of hyperlipidemic mice fed with HFD, and furthermore, significantly inhibited the pro-inflammatory cytokine expressions of IL-6, TNF-α, IL-1β, and IL-8 in HFD-induced hyperlipidemia mouse models. The gene discussed is TNF; the disease is hyperlipidemia.