Five out of the ten top hub nodes from general glioma networks from StringDB and BioGRID are matching genes containing erb-b2 receptor tyrosine kinase 2 (HER2), erb-b2 receptor tyrosine kinase 4 (HER4), cyclin D3 (CCND3), TEK tyrosine kinase (TEK), and transforming growth factor alpha (TGFA). Here, ERBB4 is linked to central nervous system cancer.