SPDL1 and hepatocellular carcinoma: Interestingly, 8/9 (89%) patients with detectable sPD-L1 levels (median: 3.51 ng/mL, range: 1.34–18.48 ng/mL) had advanced HCC (BCLC C) and 1/9 (11%) had BCLC A (Table 3).