Similar deficits in cardiac SIRT3, together with attendant alterations in mitochondrial morphosis and mitophagy, have also been described in murine models of type-2 diabetes [343,347] Accordingly, whether the potential infarct-sparing effect of strategies targeting mitochondrial quality control would be maintained in aging and diabetic populations (or in the setting of any relevant comorbidities) is, at present, unknown, and conclusions regarding future translational relevance would be premature. Here, SIRT3 is linked to type 2 diabetes mellitus.