Casticin induced cytotoxicity and reduced cell proliferation by blocking the phosphorylation of Akt (Ser473) and mTOR (Ser2448) proteins, indicating the involvement of Akt/mTOR signaling pathway, in human breast cancer MCF-7, gastric cancer SNU16, and myeloma RPMI 8226 cells [26]. This evidence concerns the gene AKT1 and plasma cell myeloma.