HIF1A and cancer: We focused our analysis on iso-sequential LNA gapmers and exhaustively varied the number and positions of LNA modifications in the flanks, thereby testing 768 gapmers across two different regions in the hypoxia-inducible factor 1-alpha (HIF1A) mRNA known to be accessible to gapmers.13, 14, 15 The HIF1A protein is a subunit of the HIF1 transcription factor that regulates cellular and developmental responses to hypoxia and elevated expression of HIF1A is associated with poor prognosis in many types of cancer.13