RHO and cancer: Importantly, within this subset we identified a number of genes not previously associated with either ethanol exposure or CRC, including KIF16B, ARHGAP32 and SUB1. ARHGAP32 in particular is an interesting finding, given that it is a gene hypothesized to play a role in regulating both RAS- and Rho- signaling pathways [31], which have often been found to be perturbed in cancers, including CRC, as reviewed in Saeed et al., 2019 [32].