The degree centrality for each protein listed in the Fig 5 is equal to or greater than the mean of degree centrality, thus, APP, LRP1, UBC, YWHAE, EGFR, ELAVL1, YWHAB, YWHAZ, SUMO1, SRC, and EGR1 are essential shared proteins, in which APP and LRP1 are also causative genes related AD. The gene discussed is EGR1; the disease is Alzheimer disease.