PIK3R1 and Alzheimer disease: For each protein in Fig 5, the node degree connecting AD and Affective Domain proteins were equal to or greater than the mean node degree, thus, RHOA, APP, UBC, YWHAE, ELAVL1, GRB2, PIK3R1, SRC, HSPA4, YWHAZ, HSP90AA1, GSK3beta, PRKCZ, and FYN were found to be essential shared proteins, in which RHOA and APP are also causative genes related AD, and GSK3beta and PRKCZ are causative genes related to Affective Domain symptoms.