SUMO1 and Alzheimer disease: The degree centrality for each protein listed in the Fig 5 is equal to or greater than the mean of degree centrality, thus, APP, LRP1, UBC, YWHAE, EGFR, ELAVL1, YWHAB, YWHAZ, SUMO1, SRC, and EGR1 are essential shared proteins, in which APP and LRP1 are also causative genes related AD.