Notably however they also exhibit quite different systemic manifestations such as fever, fatigue, and loss of appetite and weight, and abnormal laboratory findings including elevated C-reactive protein (CRP), anemia, hypoalbuminemia, hypocholesterolemia, and thrombocytosis with poor prognosis, which are reportedly associated with a condition known as hyper- interleukin (IL)-6 syndrome that is characterized by elevated serum IL-6. The gene discussed is CRP; the disease is Hypocholesterolemia.