HuR is a well‐known RNA‐binding protein that prevents mRNA decay via targeting the uridylate‐rich element (ARE, (A/U)UUU(A/U)) on the 3′‐UTR.26 A wealth of studies have demonstrated that HuR is ubiquitously expressed in eukaryotic organization and frequently elevated in human cancers, including LSCC.27 CCND1 is one of the best‐known HuR targets, in which HuR increases the half‐life of CCND1 by the ARE motif on CCND1 3′‐UTR.28 In our study, circ‐CCND1 was shown to interact with HuR and facilitate its enrichment on CCND1 3′‐UTR, thereby increasing CCND1 mRNA stability. The gene discussed is CCND1; the disease is cancer.