All of the 18 AD risk genes are expressed in microglia according to the expression data from Zeisel et al (see Fig 4A; Zeisel et al, 2015) and are predicted SPI1 targets according to i‐cisTarget (see Fig 4C), and 11 out of these (APOE, BLNK, HEXB, INPP5D, LYN, PLCG2, RRBP1, SAMSN1, SLC2A5, SPI1, SYK) are demonstrated SPI1 targets in a ChIPseq experiment in the BV2 microglia cell line (Satoh et al, 2014). Here, APOE is linked to Alzheimer disease.