We identify in this module 7 established AD risk genes (APOE,CLU,INPP5D,CD33, PLCG2,SPI1, and FCER1G) and 11 AD GWAS genes below the genome‐wide significance threshold (GPC2, TREML2, SYK, GRN, SLC2A5, SAMSN1, PYDC1, HEXB, RRBP1, LYN, and BLNK), that become significantly upregulated when exposed to Aβ. This evidence concerns the gene PLCG2 and Alzheimer disease.