Results of multivariable logistic regression analysis revealed that OPG [adjusted odds ratio (aOR) 1.027, 95% confidence interval (CI) 1.010–1.045, p = .002] and CRP (aOR 1.102, 95% CI 1.006–1.207, p = .037) levels were independent predictors of PAD in patients on PD. This evidence concerns the gene CRP and peripheral arterial disease.