MAPT and Alzheimer disease: Ceramides have been shown to stimulate ß‐amyloid formation, the pathological hallmark of AD, through regulating ß‐site amyloid precursor protein cleaving enzyme 1 (BACE‐1) activity,37, 38 while inhibition of ceramide synthesis results in reduced production of ß‐amyloid.37, 38, 39, 40 There is also evidence to support a role for ceramides in tau phosphorylation.