SAMHD1 and acute myeloid leukemia: Clinical responses to ara‐C correlate with accumulation of the active metabolite ara‐CTP in AML cells (Plunkett et al, 1985), which is strongly regulated by the dNTPase SAMHD1 (Schneider et al, 2016; Herold et al, 2017a,b,c; Hollenbaugh et al, 2017; Rudd et al, 2017; Rassidakis et al, 2018).