In total, 29 of the primary tumours (5%) had mean MRPS23 copy number ≥ 4 < 6, 21 (4%) had mean copy number ≥ 6 and 41 (7%) had MRPS23/CEP17 ratio ≥ 2 (Table 1, Fig. 2). The gene discussed is MRPS23; the disease is neoplasm.