André André F F Ciruelos Ciruelos E E Rubovszky Rubovszky G G Alpelisib for PIK3CA-mutated, hormone receptor–positive advanced breast cancer Alpelisib for PIK3CA-mutated, hormone receptor–positive advanced breast cancer N Engl J Med N Engl J Med 2019 2019 380 380 1929 1929 1940 1940 10.1056/NEJMoa1813904 10.1056/NEJMoa1813904 supplied-pmid 31091374? The gene discussed is PIK3CA; the disease is breast cancer.