Of note, the median urinary CN-1 concentrations of healthy individuals were significantly lower compared to those of T2DM patients with macroalbuminuria (p < 0.0001), and healthy individuals showed with borderline significance lower urinary CN-1 concentrations compared to the nondiabetic group with macroalbuminuria (p = 0.05) (data not shown). This evidence concerns the gene CNDP1 and type 2 diabetes mellitus.