ITGB2 and renal cell carcinoma: The PPI network analysis also identified the top ten hub genes of RCC, which included protein tyrosine phosphatase, receptor type C (PTPRC), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), fibronectin 1 (FN1), CD44 molecule (CD44), integrin subunit alpha M (ITGAM), epidermal growth factor (EGF), CD86 molecule (CD86), integrin subunit beta 2 (ITGB2), and Toll-like receptor 2 (TLR2).