Knowing that FoxO1 is a positive regulator of bone formation through its resistance to oxidative stress in osteoblast [12], and iron overload induces oxidative stress, bone loss, and osteoporosis, we postulated that CUR may be able to exert an effect on FoxO1 and affect the transcription of target genes to regulate oxidative stress and bone remodeling. This evidence concerns the gene FOXO1 and osteoporosis.