FOXO1 and type 2 diabetes mellitus: (iv) Accumulated p62, loss of FOXO1/3, and increased oxidative damage occur in aged rat liver, whereas accumulated p62, upregulated FOXO1/3, and reduced ROS level coexist in the liver of a type 2 diabetes mice model, suggesting that the p62-FOXO1/3 axis is involved in liver aging but not dominant in diabetic liver