We observed increased p62 along with a decreased ratio of LC3II to LC3I in the liver of ob/ob or db/db mice compared with those in the liver of c57 mice (Figures 4(e) and 4(f); ), indicating the attenuation of autophagy activity in the liver of both type 2 diabetes mice models, which could have contributed to the exacerbation of hepatic steatosis and insulin resistance. Here, SQSTM1 is linked to type 2 diabetes mellitus.