Based on dynamic observation of hepatitis B e antigen (HBeAg) status, serum hepatitis B virus (HBV) DNA, and alanine transferase (ALT) levels, the natural history of chronic HBV infection can typically be divided into four successive phases: HBeAg-positive chronic infection, HBeAg-positive chronic hepatitis, HBeAg-negative chronic infection, and HBeAg-negative chronic hepatitis [1]. Here, GPT is linked to chronic hepatitis.