KRT88P and Cirrhosis: Therefore, this study selected single tradeoff cutoffs [22, 23], which minimize not only the misdiagnosis for predicting significant hepatic necroinflammation and fibrosis (pathological grades ≥G2 and stages ≥S2) but also the missed diagnosis for predicting extensive hepatic necroinflammation and cirrhosis (pathological grades ≥G3 and stages =S4), to evaluate the performance of anti-HBc and serum HBsAg and HBV DNA in predicting liver necroinflammation intensities and fibrosis levels.