However, the serial test of combination of anti-HBc and serum HBsAg of HBeAg-positive patients and of anti-HBc and serum HBV DNA of HBeAg-negative patients can all achieve satisfactory specificities for predicting significant liver necroinflammation and fibrosis, and the parallel test of combination of which can also obtain satisfactory sensitivity for predicting extensive liver necroinflammation and cirrhosis. The gene discussed is KRT88P; the disease is fibrosis.