In addition, the low expression of PSMB8, IFI44L, IFIT3, ISG15, OAS1, SAMD9, BST2, IFI27, IFIT1, or OAS2 was associated with the poorer overall survival of HER2-GC patients (P < 0.05) (Table 3). This evidence concerns the gene ISG15 and gastric cancer.