If 1% TPS was used as a threshold, 8/30 (26.7%) of the metastatic lesions had inconsistent PD-L1 expression compared to the primary tumor tissue (k = 0.54, and P < 0.001), among which, 7 (23.4%) cases had reduced PD-L1 expression and 1 (3.3%) case had increased PD-L1 expression in the metastasis lesions. The gene discussed is CD274; the disease is neoplasm.