PDK1 and liver cancer: To investigate the effects of PDK1 inhibition on liver cancer, we first examined the viability of HepG2 and HepG3B cells after treatment with PDK1 inhibitor-DCA for 24 h and 48 h.The results showed that, DCA reduced the viability of HepG2 and HepG3B cells in a dose-dependent manner (Fig. 1A-B).