The 5-year survival analysis of joint effects were statistically different between group of score=1(p53/p21) and group of score=0 in 419 case tissues (P=0.027), group of score=1 relative to group of score=0 is a protective factor for the prognosis of liver cancer (HR=0.697, 95% CI=0.506-0.960). Here, CDKN1A is linked to liver cancer.