The 2-year survival analysis of joint effects were statistically different between group of score=1 (P21/NM23/VEGF) and group of score=0 in 419 case tissues (P=0.043), group of score=1 relative to group of score=0 was a protective factor for the prognosis of liver cancer (HR=0.477, 95% CI=0.233-0.979). Here, VEGFA is linked to liver cancer.