As shown in Table 4, the 2-year survival analysis of joint effects were statistically different between group of score=2 (p53/VEGF) and group of score=0 (p53/VEGF) expression in 419 case tissues (P=0.047), p53/VEGF relative to p53/VEGF (+/+) was a protective factor for the prognosis of liver cancer (HR=0.450, 95% CI=0.205-0.988). Here, TP53 is linked to liver cancer.