IL10 and neoplasm: TAMs are involved in the promotion of tumor progression, like mammary cancer and pancreatic carcinoma from multiple profiles containing angiogenesis, migration and invasion, epithelial-mesenchymal transition (EMT), intravasation and extravasation of tumor cells, immunologic suppression, chemoresistance, and immunosuppression 50, and TAM-secreted IL-10 limits the expression of IL-12, which is one of the anti-tumor cytokines 51.