For instance, deleted in liver cancer-1 (DLC1) is a relatively new ligand for S100A10 and a mediator, negatively regulating cell growth in non-small cell lung cancer (NSCLC) through competitive binding of S100A10 with Annexin A2, resulting in rapid ubiquitin-mediated degradation of S100A10 47. The gene discussed is DLC1; the disease is non-small cell lung carcinoma.