We found FGF14 was downregulated or silenced in all (10/10) CRC cell lines, while it was expressed in normal colonic cell line NCM460 and tissues through RT-PCR, which was validated by Western blot in six CRC cell lines including CaCO2, DLD1, HCT116, HT29, LOVO and SW620 and in normal colon epithelial cell line NCM460 (Fig. 1A). Here, FGF14 is linked to colorectal carcinoma.