Notably, patients with ARID1A alterations were correlated with markedly high immune infiltrates in endometrial, stomach and colon cancer but dramatically lower CD8+ T cell infiltrations in ARID1A-mutant renal clear cell carcinoma, indicating the association between ARID1A alterations and immune infiltrates was cancer-dependent. This evidence concerns the gene ARID1A and malignant colon neoplasm.