It is reported that quercetin prevented cardiac hypertrophy by proteasome inhibition and activation of GSK-3α/β, which is related to upstream (AKT, LKB1/AMPKα) and downstream hypertrophic factors, such as ERK, histone H3, β-catenin, and GATA4 [32]. This evidence concerns the gene STK11 and cardiac hypertrophy.