Firstly, GABARAP was decreased in the heart of ISO-induced rats and in angiotensin II-incubated HUVEC cells, whereas it was upregulated by Granule of BU-XIN RUAN-MAI, implying that GABARAP-mediated autophagy might be involved in Granule of BU-XIN RUAN-MAI alleviating heart disease. This evidence concerns the gene GABARAP and heart disorder.