Furthermore, knockdown of GABARAP could significantly reverse the Granule of BU-XIN RUAN-MAI-controlled expression of genes including PPARα, IL-6, IL-1β, and TNFα, SOD1, and MDA in vivo and in vitro, suggesting that Granule of BU-XIN RUAN-MAI shows its inhibitory activity against oxidation and inflammation in angina pectoris of heart disease partly depending on the GABARAP expression. Here, SOD1 is linked to heart disorder.