The macroscopic observation scores, mucosal injury index scores, and esophageal inflammation scores were decreased, which presented that ZHG protected the mucosal injury and inflammatory damage; the levels of GAS, MTL, and VIP in serum of rats with reflux esophagitis were decreased; the result shows that the ZHG regulates the serum gastrointestinal hormone levels. The gene discussed is VIP; the disease is inflammation.