ARSB and neoplasm: Since sulfation of CS has been reported to decrease Gal-3 affinity for CS [17, 47], we can hypothesize that a reduction in Gal-3 levels in the primary tumor over the course of tumor progression, concomitantly with an increase in CHST11 and decrease in ARSB expression, might contribute to a delocalization of Gal-3 to the intracellular milieu of tumor cells.