Interestingly, in the absence of Gal-3 in the tumor microenvironment (Lgals3−/−), there was a reduction in the mRNA levels of CHST11 in 4T1-shRNA-Gal-3-derived tumors in comparison with 4T1-scramble-derived tumors (Figure 7(f)). The gene discussed is LGALS3; the disease is neoplasm.