Thus, it is advisable to combine the BMPR1A, SMAD4, CDH1, TP53, STK11 and PTEN genes into a targeted sequencing panel that will provide significant information on the mutational profile of gastric tumours in both hereditary and sporadic cancer, which can be associated with the clinical and pathomorphological features of the disease. The gene discussed is TP53; the disease is gastric neoplasm.