Immunofluorescence co-staining using anti-mouse CD31 antibody and TUNEL on the excised A2780cp20 tumors revealed that, in comparison with untreated control tumors, both BIDEN-AP and CCPM-BIDEN-AP induced apoptotic cell death in CD31+ endothelial vasculature within tumor stroma; suppressed angiogenesis in tumors as indicated by decreased microvessel density (Fig. 6A–C); and significantly reduced tumor cell proliferation, as evidenced by the decreased number of Ki67-positive cells (Fig. 6D,E). Here, PECAM1 is linked to neoplasm.