Integrated pathway analysis of reverse-phase protein array data showed that: 1) regulation of EMT was among the top pathways downregulated by BIDEN-AP, and 2) important regulators involved in tumor-associated angiogenesis, including EGFR, VEGFR2, GAB2, and JAK2, were significantly downregulated by BIDEN-AP, suggesting that the activity of receptor tyrosine kinase–mediated signal transduction pathways EGFR/MAPK14(Crk1)/JAK2 was decreased by BIDEN-AP–based agents. This evidence concerns the gene KDR and neoplasm.