While studying the functional activity of TNYL-RAW analogues with high EphB4 binding affinity, we discovered that one such analogue, TNd(Y)LFSPNGPIARAW, in which the L-Tyr-P3 was substituted by a D-Tyr, induced EphB4 phosphorylation in human HeyA8 ovarian cancer cells (Fig. 1A, Supplementary Data Fig. S3, Table S1). Here, EPHB4 is linked to ovarian carcinoma.