We performed multivariate analysis of the cumulative rate of MAOs with clinical characteristics as covariates; the results showed that penetrating type disease, CRP ≥ 0.5 mg/dL, and Alb < 3.8 g/dL at week 8 were independent risk factors for MAOs (hazard ratios: 2.16, 2.06, and 2.08, respectively). The gene discussed is CRP; the disease is glycogen storage disease VI.