The list of 285 candidates comprises well known CRC driver genes such as TP53, KRAS, AXIN2 and ERBB2, although among the top twenty-five were identified 15 genes related to CRC pathogenesis such as CEBPZ, RRBP1, FXR1, LRPPRC, NAP1L1, AHCY, ALDH1A1, HNRNPU, ITGB1, KEAP1, NCL, OLA1, PLEC, REG4, YME1L1. Here, REG4 is linked to colorectal carcinoma.