The significant DEGs overexpressed in CRC were enriched in proteins that have key roles in cell cycle, p53 signalling pathway, Serine biosynthesis glycerate-3P => serine (KEGG amino acid metabolism pathway module), biosynthesis of amino acids, WNT signalling pathway, microRNA in cancer and inosine monophosphate biosynthesis, PRPP + glutamine => IMP (KEGG purine metabolism pathway module). This evidence concerns the gene TP53 and cancer.