As in cancer cells17, AD epichaperomes contained hub proteins, such as HSP90, HSC70, HSP110, HOP, and CDC37 (Fig. 2b, c), independent of the total expression of these individual chaperones (Fig. 2b, f and Supplementary Fig. 3D), and unlike the folding chaperones HSP90 and HSP7013,14, epichaperomes in the AD brain did not bind to hyperphosphorylated tau or to full-length APP (Fig. 2d). Here, HSP90AB1 is linked to Alzheimer disease.