We found human AD brains, but not age-matched non-demented (ND) brains, contained a significantly higher fraction of the total chaperome rewired into epichaperomes (see Fig. 2b and Supplementary Fig. 3D for epichaperome network hubs such as HSP90, HSP-organizing protein (HOP) and HSC70)17,21, and demonstrated a pattern of distinct interactions (see Fig. 2b native PAGE for HSP90, HSC70, HOP and CDC37). Here, HSPA8 is linked to Alzheimer disease.