For example, two hominin-specific PFC gains that were reduced in ASD brains were linked to DNMT3A and CAMK2A by HiC data (Fig. 4d, c, Supplementary Fig. 8c, d), the latter of which was shown to regulate dendritic morphology and synaptic transmission49 and is found mutated in autism patients50. Here, DNMT3A is linked to autism.