KDELR3 and melanoma: We used human and mouse melanoma cells to demonstrate that siRNA and short-hairpin RNA (shRNA) knockdown of KDELR3 significantly reduced, and KDELR3 overexpression enhanced, anchorage-independent growth (Fig. 3a–d; Supplementary Fig. 5a, b), which cannot be attributed to a change in proliferation (Supplementary Fig. 5c).