KDELR3 and melanoma: Transient knockdown of KDELR3 in either mouse (Fig. 3h, i) or human melanoma cell lines (Fig. 3j, Supplementary Fig. 6a) resulted in significantly reduced metastatic potential compared with non-targeting controls, indicating that KDELR3 expression is important for the cells’ ability to extravasate/colonize the lung, further validating that KDELR3 is a melanoblast gene that functions in metastasis (MetDev gene).