Gene set enrichment analysis (GSEA, false discovery rate (FDR) <0.0001) of KDELR3-co-expressed genes in TCGA skin cutaneous melanoma patients (cBioPortal)30,31 revealed gene ontology (GO) term enrichment of ECM and trafficking pathways (consistent with previous data, Supplementary Figs. 2a and 7a), and pathways involved in the ERSR and response to unfolded proteins (Supplementary Fig. 7a). Here, KDELR3 is linked to cutaneous melanoma.