In addition, our previous study has shown that tumour-targeted delivery of Fas-associated protein with death domain (FADD), which is the key adaptor protein for the apoptotic signal transduction that activates caspase-8 and leads to extrinsic apoptosis, suppresses B16F10 melanoma cells by enhancing auto-initiated apoptosis16. The gene discussed is FADD; the disease is neoplasm.