BRCA1 and breast cancer: We found no significant association between RRSO and breast cancer risk for BRCA1 or BRCA2 mutation carriers, although the point estimate for the association for BRCA2 mutation carriers was less than 1 (HR = 0.88 (95% CI 0.62–1.24)) and lower when RRSO was carried out before the age of 45 (HR = 0.68 (95% CI 0.40–1.15) vs 1.07 (95% CI 0.69–1.64) after age 45).