Among 2272 BRCA1 and 1605 BRCA2 mutation carriers without a previous diagnosis of cancer or RRM, 269 BRCA1 and 157 BRCA2 mutation carriers were diagnosed with breast cancer during follow-up (mean follow-up time 5.4 and 4.9 years for BRCA1 and BRCA2, respectively; Tables 1 and 2). The gene discussed is BRCA2; the disease is breast carcinoma.