Moreover, we showed that Ang II stimulates the production of 6β-OHT in Cyp1b1+/+, but not Cyp1b1−/− mice, and it is required (i.e., acts as a permissive factor) for Ang II-induced hypertension and associated cardiac remodeling and renal dysfunction [16, 17]. This evidence concerns the gene AGT and Abnormal renal physiology.