From this comprehensive analysis of circRNA expression profiles in MM, (1) we found that circRNA expression patterns were able to distinguish MM patients from HCs, and there were 122 upregulated and 260 downregulated circRNAs in MM compared with HCs, which were implicated in neoplastic signaling pathways such as MAPK signaling pathways and VEGF signaling pathway. This evidence concerns the gene VEGFA and Miyoshi myopathy.