The 5 upregulated (Fig. 6a) and 6 downregulated (Fig. 6b) circRNAs were then included in the ROC analysis, which illuminated that circ-PTK2 (AUC: 0.814, 95% CI: 0.729–0.900), circ-RNF217 (AUC: 0.672, 95% CI: 0.562–0.783), circ-RERE (AUC: 0.725, 95% CI: 0.620–0.830), circ-NAGPA (AUC: 0.804, 95% CI: 0.714–0.895), circ-KCNQ5 (AUC: 0.704, 95% CI: 0.594–0.815) could predict higher MM risk. This evidence concerns the gene RERE and Miyoshi myopathy.