The correlation of candidate circRNAs with treatment response in MM patients was assessed and we observed that, in the top 10 upregulated circRNAs, circ-PTK2 (P = 0.015) was associated with reduced CR; circ-RNF217 (P = 0.020) and circ-SETD5 (P = 0.029) were correlated with lower ORR (Table 5). The gene discussed is RNF217; the disease is Miyoshi myopathy.