Its over-expression may also explain why a subgroup of PBC patients lack AMA or have diminished titres, miR-150 is interrelated and arguably plays its own role, their close interplay governing several of the key elements in the pathogenesis of PBC, as we have noted by the demonstration of the participation of their downstream regulators RASGRP1 and DNMT1. The gene discussed is RASGRP1; the disease is primary biliary cholangitis.