DNMT1 and primary biliary cholangitis: Next, we assessed the expression of both microRNAs in PBMCs. We found that the expression of miR-21 was enhanced 1.7 times in PBC (p = 0.002 vs. controls, Fig. 4a), and it was accompanied by downregulation of its downstream target RASGRP1 mRNA (67% reduction; p = 0.002 vs. controls; Fig. 4b), as well as the downregulation of DNMT1 (80 and 83% reduction of mRNA and protein level, respectively; p = 0.002, and p < 0.0001vs.controls, respectively, Fig. 4c).