Particularly, a more recent study from Huang et al. [30] pointed out that the expression levels of Notch2 and its ligand Jagged-1 substantially correlated with the degree of interstitial fibrosis in several different kidney fibrosis models including folic acid (FA)-induced nephropathy, unilateral obstruction (UUO), or apolipoprotein L1 (APOL1)-associated kidney disease. The gene discussed is APOL1; the disease is kidney disorder.