Moreover, STIM1-Orai1-TRPC1-dependent Ca2+ currents have been associated to the Ca2+ mobilization responsible for the development of distinct cancer hallmarks in different cancer cell types, including prostate cancer cells [75] and colon cancer cells [76,77], while STIM1-Orai1-TRPC1-TRPC4-mediated Ca2+ currents are involved in the Ca2+ remodelling involved in hypertrophic cardiomyopathy in rat ventricular myocytes [78]. Here, ORAI1 is linked to hypertrophic cardiomyopathy.