In particular, this cytokine induces the generation from CD49a-CD49b+EOMES+ NK cells of CD49a+CD49b+EOMES+ intermediate type1 ILCs (intILC1) and CD49a+CD49b-EOMESint ILC1s; interestingly, the frequency of these two last populations increases during cancer progression, while NK cell number declines. The gene discussed is ITGA1; the disease is cancer.