Indeed, we further observed that inhibition of FGF-signaling by using the selective FGFR1-3 inhibitor or depletion of FGFR2 by corresponding siRNAs substantially enhanced the cytotoxic and pro-apoptotic effects of IM in IM-resistant GIST cells (unpublished data). This evidence concerns the gene FGFR2 and gastrointestinal stromal tumor.