Similarly, the knockdown of FGFR2 in Dox-treated GIST substantially decreased the amount of Rad51 precipitated by γ-H2AX-Abs (Figure 4F—right bottom panel), thereby confirming a strong impact of FGFR2-signaling in the recruitment of Rad51 to DSBs in DNA damaging conditions. The gene discussed is H2AX; the disease is gastrointestinal stromal tumor.